Trastuzumab in inflammatory breast cancer

Trastuzumab in inflammatory breast cancer.

Trastuzumab-Resistance and Breast Cancer

Evolution of therapeutic monoclonal antibodies significantly benefited from the recombinant DNA technologies that are used to generate chimeric, humanized, and human versions of monoclonal antibody to reduce the problem of immunogenicity and neutralization, as well as from understanding mechanisms of action mediated by monoclonal antibodies (Nelson et al., 2010; Reichert, 2009; Ranson & Sliwkow...

Adjuvant trastuzumab in HER2-positive breast cancer.

BACKGROUND Trastuzumab improves survival in the adjuvant treatment of HER-positive breast cancer, although combined therapy with anthracycline-based regimens has been associated with cardiac toxicity. We wanted to evaluate the efficacy and safety of a new nonanthracycline regimen with trastuzumab. METHODS We randomly assigned 3222 women with HER2-positive early-stage breast cancer to receive ...

Trastuzumab use in breast cancer: clinical issues.

BACKGROUND Overexpression of the epidermal growth factor 2 HER2 in breast cancer tissue is associated with shorter survival. Trastuzumab, a monoclonal antibody against HER2, can induce tumor responses when given alone and enhances the effectiveness of several chemotherapeutic agents. METHODS The recent clinical data on outcomes regarding testing for HER2 overexpression and the tolerance, toxi...

Her2 and trastuzumab in breast cancer.

The pace of development of new, clinically relevant information in this area can induce difficulties for clinicians in oncology to become fully aware of and quickly react to these advances. Several recent meetings have reported results that are pertinent to the field of HER2/neu and trastuzumab use in breast cancer. This article summarizes some points on HER2 testing and trastuzumab use that sh...